histonedeacetylase相关论文
Nucleolus is a membrane-less organelle where ribosomes are assembled,and ribosomal RNAs(rRNAs)transcribed and processed.......
Inhibition of histone deacetylase 2 mitigates profibrotic TGF-β1 responses in fibroblasts derived fr
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HDAC1 Inhibition overcomes Temozolomide Resistance by targeting NF-κB-dependent Transcription in Gli
目的 Glioblastoma(GBM)is the most frequent and aggressive tumour in the centralnervous system(CNS).Here,we show that RGF......
Pharmacological inhibition of HDAC6 alleviates brain infarction and functional deficits after experi
Objective Histone deacetylase(HDAC)6 exists exclusively in the cytoplasm and deacetylates cytoplasmic proteins such as ......
Histone Deacetylase is Essential for Epigenetic Regulation of Thy-1 Gene Expression during Lipopolys
Lipopolysaccharide (LPS)-induced proliferation of lung fibroblasts is closely correlated with loss of gene expression of......
Both kinetic metabolic fluxes and expression of metabolic genes display robust circadian rhythms across all major metabo......
Identification and Structure-Activity Relationships of Novel Dual-acting Agents to Improving Therape
The development of estrogen receptor(ER)ligands has emerged as active study field in fight against breast cancer,some of......
Evodiamine-inspired Dual Histone Deacetylase 1(HDAC1)and Topoisomerase 2(Top 2)Inhibitors with Poten
A great challenge in multi-targeting drug discovery is to identify drug-like lead compounds with therapeutic advantages ......
Suberoylanilide hydroxamic acid overcomes erlotinib-acquired resistance via phosphatase and tensin h
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目的探讨组蛋白去乙酰化酶11(HDAC11)抗乙肝病毒(HBV)的体内效果和毒性。方法选取4~6周龄雄性C57BL/6 (H-2b)小鼠，通过尾静脉高压水......
The haploid multicellular male gametophyte of plants, the pollen grain, is a terminally differentiated structure who......
Ⅱ类组蛋白去乙酰化酶(HDACs)包括HDAC4、5、7和9,它们能够发生磷酸化作用和介导核质转位。HDACs在肝、脂肪组织中的糖脂代谢中发......
Histone acetylation of the htr3a gene in the prefrontal cortex of Wistar rats regulates ethanol-seek
Previous reports showed that decreased histone deacetylase activity significantly potentiated the rewarding effects of p......
Although the involvement of gender in epigenetic machinery in peripheral tissues during the neonatal period has been sug......
胶质瘤是常见的中枢神经系统肿瘤，组蛋白去乙酰化酶( HDACs)是最新发现的一系列致癌因子，在很多实体肿瘤中发挥重要作用，在脑胶质瘤中......
组蛋白乙酰化酶(HATs)与组蛋白去乙酰化酶(HDACs)分别催化组蛋白的乙酰化与去乙酰化过程,组蛋白及特定基因的乙酰化修饰对于基因的......
目的 研究丙戊酸(VPA)对致死性烫伤大鼠心肌的保护作用及机制.方法 78只雄性SD大鼠按随机数字表法分为假烫组(n=10)、假烫+VPA组(n......
目的观察组蛋白去乙酰化酶（HDAC）抑制剂正丁酸（BA）抑制脂多糖（LPS）诱导小鼠肺纤维化过程的作用，并探讨其作用机制。方法将30只C57/BL6小鼠......
The Arabidopsis thaliana RPD3-type histone deacetylases have been known to form conserved SIN3-type histone deacetylase ......
AIM： To explore the effect of the histone deacetylaseinhibitor givinostat on proteins related to regulation ofhepatic ste......
